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1

Modifying Enzymes are Elicited by ER Stress, Generating Epitopes that are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes

Marre, Meghan L., McGinty, John W., Chow, I-Ting, DeNicola, Megan E., Beck, Noah W., Kent, Sally C., Powers, Alvin C., Bottino, Rita, Harlan, David M., Greenbaum, Carla J., Kwok, William W., Piganelli

Journal:

Year:

2018

Language:

english

File:

PDF, 1.95 MB

english, 2018

2

Human C-peptide antagonises high glucose-induced endothelial dysfunction through the nuclear factor-κB pathway

P. Luppi, V. Cifarelli, H. Tse, J. Piganelli, M. Trucco

Journal:

Year:

2008

Language:

english

File:

PDF, 417 KB

english, 2008

3

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities

Ines Batinic-Haberle, Ivan Spasojevic, Hubert M. Tse, Artak Tovmasyan, Zrinka Rajic, Daret K. St. Clair, Zeljko Vujaskovic, Mark W. Dewhirst, Jon D. Piganelli

Journal:

Year:

2012

Language:

english

File:

PDF, 1.03 MB

english, 2012

4

Erratum to: Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities

Ines Batinic-Haberle, Ivan Spasojevic, Hubert M. Tse, Artak Tovmasyan, Zrinka Rajic, Daret K. St. Clair, Zeljko Vujaskovic, Mark W. Dewhirst, Jon D. Piganelli

Journal:

Year:

2012

Language:

english

File:

PDF, 209 KB

english, 2012

5

Deletion of a single mevalonate kinase (Mvk) allele yields a murine model of hyper-IgD syndrome

E. J. Hager, H. M. Tse, J. D. Piganelli, M. Gupta, M. Baetscher, T. E. Tse, A. S. Pappu, R. D. Steiner, G. F. Hoffmann, K. M. Gibson

Journal:

Journal of Inherited Metabolic Disease

Year:

2007

Language:

english

File:

PDF, 374 KB

english, 2007

6

Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome (HIDS)

Elizabeth J. Hager, Jon D. Piganelli, Hubert M. Tse, K. Michael Gibson

Journal:

Journal of Inherited Metabolic Disease

Year:

2012

Language:

english

File:

PDF, 365 KB

english, 2012

7

Autoreactive T-cell responses: new technology in pursuit of an old nemesis

Jon D Piganelli, Clayton E Mathews

Journal:

Pediatric Diabetes

Year:

2007

Language:

english

File:

PDF, 50 KB

english, 2007

8

Preeclampsia Activates Circulating Immune Cells with Engagement of the NF-κB Pathway

Patrizia Luppi, Hubert Tse, Kristine Y. Lain, Nina Markovic, Jon D. Piganelli, Julie A. DeLoia

Journal:

American Journal of Reproductive Immunology

Year:

2006

Language:

english

File:

PDF, 258 KB

english, 2006

9

Chromogranin A is an autoantigen in type 1 diabetes

Stadinski, Brian D, Delong, Thomas, Reisdorph, Nichole, Reisdorph, Richard, Powell, Roger L, Armstrong, Michael, Piganelli, Jon D, Barbour, Gene, Bradley, Brenda, Crawford, Frances

Journal:

Nature Immunology

Year:

2010

Language:

english

File:

PDF, 697 KB

english, 2010

10

Analysis of Leukocytes Recruited to the Pancreas by Diabetogenic T Cell Clones

Jeffrey D. Peterson, Rance Berg, Jon D. Piganelli, Michelle Poulin, Kathryn Haskins

Journal:

Cellular Immunology

Year:

1998

Language:

english

File:

PDF, 145 KB

english, 1998

11

Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: implication for their use in targeting oxidation–reduction reactions in innate immunity

Hubert M Tse, Martha J Milton, Jon D Piganelli

Journal:

Free Radical Biology and Medicine

Year:

2004

Language:

english

File:

PDF, 1.08 MB

english, 2004

12

Redox modulation inhibits CD8 T cell effector function

Martha M. Sklavos, Hubert M. Tse, Jon D. Piganelli

Journal:

Free Radical Biology and Medicine

Year:

2008

Language:

english

File:

PDF, 735 KB

english, 2008

13

Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat

Huaxin Sheng, Wei Yang, Shiro Fukuda, Hubert M. Tse, Wulf Paschen, Kwame Johnson, Ines Batinic-Haberle, James D. Crapo, Robert D. Pearlstein, Jon Piganelli, David S. Warner

Journal:

Free Radical Biology and Medicine

Year:

2009

Language:

english

File:

PDF, 438 KB

english, 2009

14

Enteric coated microspheres as an oral method for antigen delivery to salmonids

Jon D. Piganelli, Jia Allen Zhang, John M. Christensen, Stephen L. Kaattari

Journal:

Fish & Shellfish Immunology

Year:

1994

File:

PDF, 402 KB

1994

15

Cytotoxic T Lymphocyte Antigen 4 (CD152) Regulates Self-Reactive T cells in BALB/c but not in the Autoimmune NOD Mouse

Jon D Piganelli, Michelle Poulin, Tracy Martin, James P Allison, Kathryn Haskins

Journal:

Journal of Autoimmunity

Year:

2000

Language:

english

File:

PDF, 191 KB

english, 2000

16

Extracellular Superoxide Dismutase in Macrophages Augments Bacterial Killing by Promoting Phagocytosis

Michelle L. Manni, Lauren P. Tomai, Callie A. Norris, L. Michael Thomas, Eric E. Kelley, Russell D. Salter, James D. Crapo, Ling-Yi L. Chang, Simon C. Watkins, Jon D. Piganelli, Tim D. Oury

Journal:

The American Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 1.22 MB

english, 2011

17

Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-κB activation in vascular smooth muscle cells

Vincenza Cifarelli, Patrizia Luppi, Hubert M. Tse, Jing He, Jon Piganelli, Massimo Trucco

Journal:

Atherosclerosis

Year:

2008

Language:

english

File:

PDF, 2.23 MB

english, 2008

18

Effects of Metalloporphyrins on Reducing Inflammation and Autoimmunity

Delmastro-Greenwood, Meghan M., Tse, Hubert M., Piganelli, Jon D.

Journal:

Antioxidants & Redox Signaling

Year:

2014

Language:

english

File:

PDF, 472 KB

english, 2014

19

mt-Nd2a Modifies Resistance Against Autoimmune Type 1 Diabetes in NOD Mice at the Level of the Pancreatic -Cell

Chen, J., Gusdon, A. M., Piganelli, J., Leiter, E. H., Mathews, C. E.

Journal:

Year:

2011

Language:

english

File:

PDF, 154 KB

english, 2011

20

Immunologic Regulation of Pancreatic Ductal Invasion of Islets

Wiersch, J., Marr, M., Gohary, Y., Xiao, X., Guo, P., Prasadan, K., Shiota, C., Piganelli, J., Gittes, G.

Journal:

Journal of Surgical Research

Year:

2013

Language:

english

File:

PDF, 75 KB

english, 2013

21

Activated Macrophages Create Lineage-Specific Microenvironments for Pancreatic Acinar- and β-Cell Regeneration in Mice

Criscimanna, Angela, Coudriet, Gina M., Gittes, George K., Piganelli, Jon D., Esni, Farzad

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 7.70 MB

english, 2014

22

Mn Porphyrin Regulation of Aerobic Glycolysis: Implications on the Activation of Diabetogenic Immune Cells

Delmastro-Greenwood, Meghan M., Votyakova, Tatyana, Goetzman, Eric, Marre, Meghan L., Previte, Dana M., Tovmasyan, Artak, Batinic-Haberle, Ines, Trucco, Massimo M., Piganelli, Jon D.

Journal:

Antioxidants & Redox Signaling

Year:

2013

Language:

english

File:

PDF, 604 KB

english, 2013

23

Neuroprotective Efficacy from a Lipophilic Redox-Modulating Mn(III) N-Hexylpyridylporphyrin, MnTnHex-2-PyP: Rodent Models of Ischemic Stroke and Subarachnoid Hemorrhage

Sheng, H., Spasojevic, I., Tse, H. M., Jung, J. Y., Hong, J., Zhang, Z., Piganelli, J. D., Batinic-Haberle, I., Warner, D. S.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2011

Language:

english

File:

PDF, 2.06 MB

english, 2011

24

Response of Human Islets to Isolation Stress and the Effect of Antioxidant Treatment

Bottino, R., Balamurugan, A.N., Tse, H., Thirunavukkarasu, C., Ge, X., Profozich, J., Milton, M., Ziegenfuss, A., Trucco, M., Piganelli, J. D.

Journal:

Year:

2004

Language:

english

File:

PDF, 735 KB

english, 2004

25

Dendritic Cells Expressing Transgenic Galectin-1 Delay Onset of Autoimmune Diabetes in Mice

Perone, M. J., Bertera, S., Tawadrous, Z. S., Shufesky, W. J., Piganelli, J. D., Baum, L. G., Trucco, M., Morelli, A. E.

Journal:

The Journal of Immunology

Year:

2006

Language:

english

File:

PDF, 1.23 MB

english, 2006

26

Modulation of Redox Balance Leaves Murine Diabetogenic TH1 T Cells "LAG-3-ing" Behind

Delmastro, M. M., Styche, A. J., Trucco, M. M., Workman, C. J., Vignali, D. A. A., Piganelli, J. D.

Journal:

Year:

2012

Language:

english

File:

PDF, 874 KB

english, 2012

27

Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility

Ge, X., Piganelli, J. D., Tse, H. M., Bertera, S., Mathews, C. E., Trucco, M., Wen, L., Rudert, W. A.

Journal:

Year:

2006

Language:

english

File:

PDF, 227 KB

english, 2006

28

Caspase-1 Is Not Required for Type 1 Diabetes in the NOD Mouse

Schott, W. H., Haskell, B. D., Tse, H. M., Milton, M. J., Piganelli, J. D., Choisy-Rossi, C. M., Reifsnyder, P. C., Chervonsky, A. V., Leiter, E. H.

Journal:

Year:

2004

Language:

english

File:

PDF, 137 KB

english, 2004

29

Preservation of Human Islet Cell Functional Mass by Anti-Oxidative Action of a Novel SOD Mimic Compound

Bottino, R., Balamurugan, A.N., Bertera, S., Pietropaolo, M., Trucco, M., Piganelli, J. D.

Journal:

Year:

2002

Language:

english

File:

PDF, 175 KB

english, 2002

30

Redox Modulation Protects Islets From Transplant-Related Injury

Sklavos, M. M., Bertera, S., Tse, H. M., Bottino, R., He, J., Beilke, J. N., Coulombe, M. G., Gill, R. G., Crapo, J. D., Trucco, M., Piganelli, J. D.

Journal:

Year:

2010

Language:

english

File:

PDF, 286 KB

english, 2010

31

Antioxidant Levels Represent a Major Determinant in the Regenerative Capacity of Muscle Stem Cells

Urish, K. L., Vella, J. B., Okada, M., Deasy, B. M., Tobita, K., Keller, B. B., Cao, B., Piganelli, J. D., Huard, J.

Journal:

Molecular Biology of the Cell

Year:

2009

Language:

english

File:

PDF, 624 KB

english, 2009

32

PS13 - 69. Innate and adaptive immune activation of human BDCA1+ myeloid dendritic cells upon encountering enterovirus-infected β-cells

Schulte, Barbara M., Kers-Rebel, Esther D., Galama, Jochem M.D., Bottino, Rita, Piganelli, Jon D., van Kuppeveld, Frank J. M., Adema, Gosse J.

Journal:

Nederlands Tijdschrift voor Diabetologie

Year:

2011

Language:

english

File:

PDF, 206 KB

english, 2011

33

PS2 - 10. Enterovirus-Infected Human Pancreatic Islets Produce Pro-inflammatory Cytokines and Chemokines and Activate Primary Human Myeloid Dendritic Cells

Schulte, Barbara M., Kers-Rebel, Esther D., Lanke, Kjerstin H.W., Engelse, Marten A., de Koning, Eelco J.P., Bottino, Rita, Piganelli, Jon D., van Kuppeveld, Frank J. M., Adema, Gosse J.

Journal:

Nederlands Tijdschrift voor Diabetologie

Year:

2012

Language:

english

File:

PDF, 308 KB

english, 2012

34

Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection

Schulte, B. M., Lanke, K. H. W., Piganelli, J. D., Kers-Rebel, E. D., Bottino, R., Trucco, M., Huijbens, R. J. F., Radstake, T. R. D. J., Engelse, M. A., de Koning, E. J. P., Galama, J. M., Adema, G.

Journal:

Year:

2012

Language:

english

File:

PDF, 1.11 MB

english, 2012

35

TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice

McKinley, L., Alcorn, J. F., Peterson, A., DuPont, R. B., Kapadia, S., Logar, A., Henry, A., Irvin, C. G., Piganelli, J. D., Ray, A., Kolls, J. K.

Journal:

The Journal of Immunology

Year:

2008

Language:

english

File:

PDF, 456 KB

english, 2008

36

NADPH Oxidase Deficiency Regulates Th Lineage Commitment and Modulates Autoimmunity

Tse, H. M., Thayer, T. C., Steele, C., Cuda, C. M., Morel, L., Piganelli, J. D., Mathews, C. E.

Journal:

The Journal of Immunology

Year:

2010

Language:

english

File:

PDF, 2.04 MB

english, 2010

37

Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes

Thayer, T. C., Delano, M., Liu, C., Chen, J., Padgett, L. E., Tse, H. M., Annamali, M., Piganelli, J. D., Moldawer, L. L., Mathews, C. E.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.15 MB

english, 2011

38

A Metalloporphyrin-Based Superoxide Dismutase Mimic Inhibits Adoptive Transfer of Autoimmune Diabetes by a Diabetogenic T-Cell Clone

Piganelli, J. D., Flores, S. C., Cruz, C., Koepp, J., Batinic-Haberle, I., Crapo, J., Day, B., Kachadourian, R., Young, R., Bradley, B., Haskins, K.

Journal:

Year:

2002

Language:

english

File:

PDF, 466 KB

english, 2002

39

TRIF and IRF-3 Binding to the TNF Promoter Results in Macrophage TNF Dysregulation and Steatosis Induced by Chronic Ethanol

Zhao, X.-J., Dong, Q., Bindas, J., Piganelli, J. D., Magill, A., Reiser, J., Kolls, J. K.

Journal:

The Journal of Immunology

Year:

2008

Language:

english

File:

PDF, 490 KB

english, 2008

40

Oxidative Stress and Redox Modulation Potential in Type 1 Diabetes

Delmastro, Meghan M., Piganelli, Jon D.

Journal:

Clinical & Developmental Immunology

Year:

2011

Language:

english

File:

PDF, 290 KB

english, 2011

41

Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice

Calabuig-Navarro, Virtu, Yamauchi, Jun, Lee, Sojin, Zhang, Ting, Liu, Yun-Zi, Sadlek, Kelsey, Coudriet, Gina M., Piganelli, Jon D., Jiang, Chun-Lei, Miller, Rita, Lowe, Mark, Harashima, Hideyoshi, Don

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 3.70 MB

english, 2015

42

Leukocyte-derived extracellular superoxide dismutase does not contribute to airspace EC-SOD after interstitial pulmonary injury

Manni, M. L., Epperly, M. W., Han, W., Blackwell, T. S., Duncan, S. R., Piganelli, J. D., Oury, T. D.

Journal:

AJP Lung Cellular and Molecular Physiology

Year:

2012

Language:

english

File:

PDF, 1.84 MB

english, 2012

43

Splenic Macrophages From the NOD Mouse Are Defective in the Ability to Present Antigen

Piganelli, J. D., Martin, T., Haskins, K.

Journal:

Year:

1998

Language:

english

File:

PDF, 1021 KB

english, 1998

44

Disruption of Innate-Mediated Proinflammatory Cytokine and Reactive Oxygen Species Third Signal Leads to Antigen-Specific Hyporesponsiveness

Tse, H. M., Milton, M. J., Schreiner, S., Profozich, J. L., Trucco, M., Piganelli, J. D.

Journal:

The Journal of Immunology

Year:

2007

Language:

english

File:

PDF, 1.10 MB

english, 2007

45

T Cell Epitopes and Post-Translationally Modified Epitopes in Type 1 Diabetes

McGinty, John W., Marré, Meghan L., Bajzik, Veronique, Piganelli, Jon D., James, Eddie A.

Journal:

Current Diabetes Reports

Year:

2015

Language:

english

File:

PDF, 1.11 MB

english, 2015

46

DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice

Chang, Y, Yap, S, Ge, X, Piganelli, J, Bertera, S, Giannokakis, N, Mathews, C, Prud'homme, G, Trucco, M

Journal:

Year:

2005

Language:

english

File:

PDF, 208 KB

english, 2005

47

Phagocytosis of Enterovirus-Infected Pancreatic -Cells Triggers Innate Immune Responses in Human Dendritic Cells

Schulte, B. M., Kramer, M., Ansems, M., Lanke, K. H. W., van Doremalen, N., Piganelli, J. D., Bottino, R., Trucco, M., Galama, J. M. D., Adema, G. J., van Kuppeveld, F. J. M.

Journal:

Year:

2010

Language:

english

File:

PDF, 552 KB

english, 2010

48

Loss of NOX-derived superoxide exacerbates diabetogenic CD4 T cell effector responses in Type 1 Diabetes

Padgett, Lindsey E., Anderson, Brian, Liu, Chao, Ganini, Douglas, Mason, Ronald P., Piganelli, Jon D., Mathews, Clayton E., Tse, Hubert M.

Journal:

Year:

2015

Language:

english

File:

PDF, 4.50 MB

english, 2015

49

FoxO1 Links Insulin Resistance to Proinflammatory Cytokine IL-1 Production in Macrophages

Su, D., Coudriet, G. M., Hyun Kim, D., Lu, Y., Perdomo, G., Qu, S., Slusher, S., Tse, H. M., Piganelli, J., Giannoukakis, N., Zhang, J., Henry Dong, H.

Journal:

Year:

2009

Language:

english

File:

PDF, 347 KB

english, 2009

50

Endoscopic biopsy of islet transplants in the gastric submucosal space provides evidence of islet graft rejection in diabetic pigs

Tanaka, Takayuki, Fujita, Minoru, Bottino, Rita, Piganelli, Jon D., McGrath, Kevin, Li, Jiang, Lee, Whayoung, Iwase, Hayato, Wijkstrom, Martin, Bertera, Suzanne, Long, Cassandra, Landsittel, Douglas,

Journal:

Year:

2016

Language:

english

File:

PDF, 1.01 MB

english, 2016

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